Pain deep in the glute can make a run feel terrible. For runners and non-runners alike, it is common to assume the issue is sciatica because the pain sits near the path of the sciatic nerve. But pain in the glute region can come from several different structures, and many of them feel very similar during running. The sciatic nerve is the largest nerve in the body. It originates from the lower back, travels through the pelvis and posterior hip, and continues down the back of t